
PDT-PDAC Project
© Meletios Verras
Photodynamic therapy to meet the challenge of treating pancreatic cancer
Keywords
pancreas, PDT, dosimetry, targeting, oxygen, in vitro, in vivo
Summary
Pancreatic cancer (PDAC) has reached a therapeutic impasse. Survival rates for patients with PDAC have barely improved over the past 50 years, highlighting the urgent need to develop new therapeutic solutions. Photodynamic therapy (PDT) is a promising strategy for the treatment of PDAC. The interdisciplinary PDT-PDAC project aims to gain a better understanding of the impact of the interaction of light and photoactivatable compounds on biological processes to optimize targeted treatment. We propose the design of 3rd generation photosensitizers and excitable nanoplatforms for targeted treatment of PDAC by PDT, which can be induced by excitation with 1 or 2 photons, Cerenkov, X-rays, or ultrasound, independent of the amount of ambient oxygen.
Scientific expectations
Manager : Valérie Heitz
Development of 3rd generation photosensitizers (PSs) and excitable nanoplatforms for targeted PDAC treatment by PDT, which can be induced by excitation with 1 or 2 photons, Cerenkov, X-rays, or ultrasound, regardless of the amount of ambient oxygen.
Manager : Anabela Da Silva
Development of suitable light sources or adaptation of existing light sources for detection (photoacoustic) or treatment (fiber laser), based on physical modeling to optimize dosimetry.
Manager : Gilles Gasser
Establishment of common characterization systems, in vitro evaluations, and in vivo models that will be used to achieve a single goal: to file a patent for a third-generation PS system associated with a light source that could be used in the clinical phase.
Manager : Nadira Delhem
Describe the mechanisms induced by these different stimuli, in particular, the action at a distance and the effect on the immune system, the detection of ROS, the measurement of temperature, and the effect on extracellular matrices.
Consortium
















PDT-PDAC project publications
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