PDT-PDAC Project
© Meletios Verras
Photodynamic therapy to face the challenge of pancreatic cancer treatment
Keywords
pancreas, PDT, dosimetry, targeting, oxygen, in vitro, in vivo
Summary
Pancreatic cancer (PDAC) is a therapeutic dead end. The survival rate of PDAC patients has remained virtually unchanged over the past 50 years, demonstrating the urgent need to develop new therapeutic solutions. Photodynamic therapy (PDT) is a promising strategy for treating PDAC. The interdisciplinary PDT-PDAC project aims to better understand the impact of the interaction between light and photoactivatable compounds on biological processes in order to optimize targeted therapeutic treatment. We propose the design of third-generation photosensitizers and excitable nanoplatforms for targeted treatment of PDAC by PDT that can be induced by 1- or 2-photon excitation, Cerenkov radiation, X-rays, or ultrasound, regardless of the amount of oxygen in the surrounding environment.
Scientific expectations
Manager : Valérie Heitz
Design of third-generation photosensitizers (PSs) and excitable nanoplatforms for targeted treatment of PDAC by PDT that can be induced by 1- or 2-photon excitation, Cerenkov radiation, X-rays, or ultrasound, regardless of the amount of oxygen in the surrounding environment.
Manager : Anabela Da Silva
Development of suitable light sources or adaptation of existing light sources for detection (photoacoustics) or treatment (fiber laser), based on physical modeling to optimize dosimetry.
Manager : Gilles Gasser
Establish common characterization systems, in vitro assessments, and in vivo models that will serve to fulfill one objective: file a patent covering a third-generation PS system associated with a light source potentially used in clinical trials.
Manager : Nadira Delhem
Provide a description of the mechanisms induced by these different excitations, in particular remote action and impact on the immune system, ROS detection, temperature measurement, and impacts on extracellular matrices.
Consortium
Publications du projet PDT-PDAC
Powered by HAL 
Les autres projets PEPR
